| | Statistic | FOR | OPP |
| Total Yards per Game | 277.9 | 336.0 |
| Rushing YDS per ATT | 4.4 | 3.3 |
| Passing YDS per ATT | 5.7 | 6.6 |
| Passing Comp % | 0.597 | 0.601 |
| Total YDS per Play | 5.1 | 5.2 |
| Total YDS per Point | 13.6 | 16.8 |
|
| Injury |
| [CB] 07/30/2009 - Walt Harris IR ( ACL ) |
| [LB] 10/19/2009 - Jeff Ulbrich IR ( Concussion ) |
| [OT] 10/27/2009 - Tony Pashos IR ( Shoulder ) |
| [OT] 11/03/2009 - Joe Staley expected to miss at least 6 weeks ( Knee ) |
| [CB] 11/02/2009 - Nate Clements expected to miss 6-8 weeks ( Shoulder ) |
| [DE] 11/17/2009 - Demetric Evans is upgraded to probable Sunday vs. Green Bay ( Shoulder ) |
| [RB] 11/19/2009 - Glen Coffee is upgraded to probable Sunday vs. Green Bay ( Neck ) |
| [WR] 11/19/2009 - Isaac Bruce is upgraded to probable Sunday vs. Green Bay ( Ankle ) |
| [LB] 11/19/2009 - Takeo Spikes is downgraded to doubtful Sunday vs. Green Bay ( Hamstring ) |