| | Statistic | FOR | OPP |
| Total Yards per Game | 562.1 | 359.1 |
| Rushing YDS per ATT | 4.8 | 3.2 |
| Passing YDS per ATT | 9.7 | 6.6 |
| Passing Comp % | 0.681 | 0.551 |
| Total YDS per Play | 7.1 | 5.1 |
| Total YDS per Point | 10.4 | 14.6 |
|
| Injury |
| (!) [QB] Sam Bradford is probable. - Thumb - 12/08/08 |
| (!) [RB] DeMarco Murray is downgraded to expected to miss - Hamstring - 12 |
| [DB] Jonathan Nelson expected to miss 6 weeks - Knee - 09/28/08 |
| [DE] John Williams is out indefinitely. - Personal - 09/02/08 |
| [DT] DeMarcus Granger expected to miss - Back - 12/17/08 |
| [LB] Austin Box is upgraded to probable - Knee - 01/05/09 |
| [LB] Ryan Reynolds out for the season - Knee - 10/11/08 |
| [WR] Tyler Stradford has left the team. - None - 10/04/08 |