| Thursday, 9/30/2021 at 8:20 PM | JACKSONVILLE (0-3) at CINCINNATI (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 101: JACKSONVILLE | 46.0 | 17.7 | 30.3 | 0-3 | 0-3-0 | 1-2-0 | -8 | 103.3 | 5.1 | 211.7 | 5.4 | 115.7 | 3.4 | 302.3 | 9.0 |
| 102: CINCINNATI | -7.5 | 22.7 | 18.0 | 2-1 | 2-1-0 | 1-2-0 | -1 | 104.7 | 3.9 | 189.3 | 7.6 | 78.3 | 3.3 | 238.7 | 5.4 |
| |
| Sunday, 10/3/2021 at 1:00 PM | WASHINGTON (1-2) at ATLANTA (1-2) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 251: WASHINGTON | 48.0 | 22.3 | 30.7 | 1-2 | 0-3-0 | 2-1-0 | -3 | 97.0 | 3.9 | 221.7 | 7.3 | 125.0 | 4.2 | 307.0 | 7.5 |
| 252: ATLANTA | +1.5 | 16.0 | 31.3 | 1-2 | 1-2-0 | 1-2-0 | -2 | 82.7 | 3.8 | 218.7 | 5.5 | 118.3 | 4.5 | 255.3 | 7.2 |
| |
| Sunday, 10/3/2021 at 1:00 PM | DETROIT (0-3) at CHICAGO (1-2) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 253: DETROIT | 42.5 | 22.3 | 31.7 | 0-3 | 2-1-0 | 2-1-0 | +1 | 105.7 | 4.5 | 247.3 | 6.0 | 114.3 | 4.2 | 269.7 | 9.6 |
| 254: CHICAGO | -3.0 | 13.3 | 25.7 | 1-2 | 1-2-0 | 1-2-0 | +1 | 101.0 | 4.2 | 90.7 | 3.2 | 119.3 | 4.2 | 231.3 | 8.0 |
| |
| Sunday, 10/3/2021 at 1:00 PM | TENNESSEE (2-1) at NY JETS (0-3) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 255: TENNESSEE | 46.0 | 23.7 | 28.0 | 2-1 | 2-1-0 | 1-2-0 | -6 | 159.3 | 4.8 | 223.3 | 6.5 | 100.0 | 4.3 | 259.3 | 7.8 |
| 256: NY JETS | +8.0 | 6.7 | 23.3 | 0-3 | 0-3-0 | 0-3-0 | -5 | 80.0 | 3.9 | 170.0 | 4.9 | 111.0 | 3.8 | 217.3 | 7.2 |
| |
| Sunday, 10/3/2021 at 1:00 PM | CLEVELAND (2-1) at MINNESOTA (1-2) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 257: CLEVELAND | 52.0 | 28.7 | 20.0 | 2-1 | 2-1-0 | 2-1-0 | -2 | 174.7 | 5.1 | 235.3 | 8.8 | 67.0 | 3.1 | 181.7 | 6.4 |
| 258: MINNESOTA | +2.0 | 29.0 | 26.0 | 1-2 | 2-1-0 | 2-1-0 | +1 | 128.0 | 4.6 | 297.0 | 7.4 | 119.3 | 4.8 | 290.3 | 9.2 |
| |
| Sunday, 10/3/2021 at 1:00 PM | INDIANAPOLIS (0-3) at MIAMI (1-2) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 259: INDIANAPOLIS | 43.0 | 18.7 | 26.7 | 0-3 | 1-2-0 | 1-2-0 | +3 | 103.0 | 4.2 | 215.3 | 5.8 | 140.3 | 4.5 | 233.0 | 8.7 |
| 260: MIAMI | -2.0 | 15.0 | 27.3 | 1-2 | 2-1-0 | 1-2-0 | +1 | 92.7 | 4.0 | 175.7 | 4.4 | 136.0 | 4.3 | 265.3 | 6.9 |
| |
| Sunday, 10/3/2021 at 1:00 PM | CAROLINA (3-0) at DALLAS (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 261: CAROLINA | 50.5 | 23.0 | 10.0 | 3-0 | 3-0-0 | 0-3-0 | +1 | 105.7 | 3.4 | 284.7 | 8.0 | 45.0 | 2.6 | 146.0 | 5.0 |
| 262: DALLAS | -4.5 | 30.0 | 23.0 | 2-1 | 3-0-0 | 2-1-0 | +5 | 139.3 | 4.6 | 277.3 | 7.5 | 70.3 | 4.7 | 331.7 | 7.7 |
| |
| Sunday, 10/3/2021 at 1:00 PM | NY GIANTS (0-3) at NEW ORLEANS (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 263: NY GIANTS | 43.0 | 18.7 | 24.7 | 0-3 | 1-2-0 | 1-2-0 | +1 | 107.7 | 4.3 | 242.7 | 7.0 | 107.0 | 4.6 | 267.3 | 6.8 |
| 264: NEW ORLEANS | -8.0 | 24.3 | 14.0 | 2-1 | 2-1-0 | 0-3-0 | +5 | 120.3 | 3.8 | 113.7 | 5.3 | 60.3 | 2.8 | 243.7 | 5.9 |
| |
| Sunday, 10/3/2021 at 1:00 PM | KANSAS CITY (1-2) at PHILADELPHIA (1-2) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 265: KANSAS CITY | 54.5 | 30.7 | 31.7 | 1-2 | 0-3-0 | 2-1-0 | -2 | 107.0 | 4.5 | 306.0 | 8.3 | 160.3 | 5.4 | 269.7 | 8.8 |
| 266: PHILADELPHIA | +7.5 | 21.3 | 21.3 | 1-2 | 1-2-0 | 1-2-0 | -1 | 129.3 | 5.4 | 247.0 | 7.6 | 133.7 | 3.8 | 181.7 | 6.0 |
| |
| Sunday, 10/3/2021 at 1:00 PM | HOUSTON (1-2) at BUFFALO (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 267: HOUSTON | 47.5 | 22.3 | 25.3 | 1-2 | 2-1-0 | 2-1-0 | +3 | 94.7 | 3.3 | 220.0 | 7.3 | 116.3 | 4.2 | 269.3 | 7.6 |
| 268: BUFFALO | -16.5 | 31.3 | 14.7 | 2-1 | 2-1-0 | 1-2-0 | +3 | 127.3 | 4.3 | 261.3 | 6.1 | 74.7 | 3.4 | 178.0 | 5.3 |
| |
| Sunday, 10/3/2021 at 4:05 PM | ARIZONA (3-0) at LA RAMS (3-0) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 269: ARIZONA | 55.0 | 34.3 | 21.7 | 3-0 | 2-1-0 | 1-2-0 | +3 | 110.0 | 3.9 | 322.3 | 9.5 | 140.7 | 5.4 | 202.0 | 5.9 |
| 270: LA RAMS | -5.0 | 31.7 | 20.7 | 3-0 | 2-1-0 | 3-0-0 | +2 | 83.7 | 3.3 | 304.3 | 9.7 | 92.7 | 4.3 | 281.3 | 6.4 |
| |
| Sunday, 10/3/2021 at 4:05 PM | SEATTLE (1-2) at SAN FRANCISCO (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 271: SEATTLE | 52.5 | 25.0 | 26.3 | 1-2 | 1-2-0 | 1-2-0 | +1 | 107.7 | 5.1 | 281.3 | 9.8 | 155.0 | 4.5 | 285.3 | 7.4 |
| 272: SAN FRANCISCO | -3.0 | 28.7 | 24.7 | 2-1 | 1-2-0 | 2-1-0 | -4 | 105.0 | 3.6 | 243.7 | 7.6 | 122.3 | 4.7 | 248.0 | 6.5 |
| |
| Sunday, 10/3/2021 at 4:25 PM | BALTIMORE (2-1) at DENVER (3-0) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 273: BALTIMORE | 44.0 | 27.3 | 28.3 | 2-1 | 1-2-0 | 2-1-0 | -2 | 185.3 | 5.7 | 239.3 | 8.3 | 79.0 | 3.6 | 314.7 | 8.0 |
| 274: DENVER | -1.0 | 25.3 | 8.7 | 3-0 | 3-0-0 | 0-3-0 | +3 | 127.3 | 4.0 | 260.0 | 8.2 | 59.3 | 3.6 | 162.3 | 4.6 |
| |
| Sunday, 10/3/2021 at 4:25 PM | PITTSBURGH (1-2) at GREEN BAY (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 275: PITTSBURGH | 45.5 | 16.7 | 22.0 | 1-2 | 1-2-0 | 0-3-0 | -1 | 53.0 | 3.2 | 255.3 | 5.9 | 88.3 | 3.6 | 266.3 | 7.5 |
| 276: GREEN BAY | -7.0 | 22.7 | 27.7 | 2-1 | 2-1-0 | 2-1-0 | +1 | 79.7 | 3.4 | 222.0 | 7.0 | 115.3 | 4.4 | 206.0 | 6.4 |
| |
| Sunday, 10/3/2021 at 8:20 PM | TAMPA BAY (2-1) at NEW ENGLAND (1-2) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 277: TAMPA BAY | 49.0 | 34.3 | 29.3 | 2-1 | 1-2-0 | 3-0-0 | -1 | 56.3 | 3.5 | 349.7 | 7.4 | 63.7 | 3.1 | 338.3 | 7.0 |
| 278: NEW ENGLAND | +7.0 | 18.0 | 17.0 | 1-2 | 1-2-0 | 0-3-0 | 0 | 91.7 | 3.9 | 226.0 | 5.7 | 122.7 | 4.0 | 159.7 | 5.9 |
| |
| Monday, 10/4/2021 at 8:15 PM | LAS VEGAS (3-0) at LA CHARGERS (2-1) | |
| Expanded Matchup | FoxSheet | Results | Offensive Statistics | Defensive Statistics |
| Teams | Line | PF | PA | SU | ATS | O/U/P | TO | RY | RYPA | PY | PYPA | RY | RYPA | PY | PYPA |
| 279: LAS VEGAS | 52.5 | 30.0 | 24.0 | 3-0 | 2-1-0 | 2-1-0 | +1 | 91.3 | 3.4 | 379.7 | 8.4 | 120.3 | 4.8 | 235.3 | 5.9 |
| 280: LA CHARGERS | -3.5 | 22.3 | 20.0 | 2-1 | 2-1-0 | 0-3-0 | +2 | 87.3 | 3.7 | 307.3 | 7.3 | 170.0 | 5.8 | 201.7 | 6.6 |
