SAN DIEGO (AP) - Will Venable hit a two-run single in the 12th inning to give the San Diego Padres a 6-5 win over the Kansas City Royals on Monday night.
Venable singled off Tim Collins (0-2) and over the head of right fielder Lorenzo Cain to score Chris Denorfia with the tying run and Yonder Alonso with the winning run from second base.
Denorfia led off the inning with a single off Louis Coleman before Collins came on. After a sacrifice, Alonso reached a bloop double to left to bring up Venable.
Mike Moustakas hit an RBI single to score Salvador Perez in the 12th off Tim Stauffer (1-0) to give the Royals a brief lead.
Jedd Gyorko's solo homer with one out in the ninth inning off Royals closer Greg Holland tied the game at 4. It was Holland's first blown save in eight chances.
Eric Hosmer homered and drove in three runs for Kansas City, which extended its season-high losing streak to five games despite a season-high 16 hits. Cain, who came off the disabled list before the game, had four hits.
Hosmer hit his first homer of the season, a solo shot off Nick Vincent, to put Kansas City ahead 4-3 in the seventh after Grandal tied the game at 3 in the bottom of the sixth with a three-run homer off Kansas City rookie Yordano Ventura.
Ventura had allowed just two hits in five shutout innings before giving up Grandal's homer. The right-hander allowed five hits, did not walk a batter and struck out a career-high 10 in six innings. Ventura extended his scoreless innings streak to 18 scoreless innings before Grandal's homer.
Ventura collected his first major league hit with a sharp single leading off the fifth. Nori Aoki followed with a single and both runners moved up on a fly out. Hosmer grounded a two-run single up the middle for a 3-0 lead.
Padres starter Eric Stults had his second tough outing as he lasted just 4 2-3 innings, allowing three runs and 11 hits. The left-hander tied a season high by allowing five runs over 2 2/3 innings - his shortest start since April 2009 - in his last start.
NOTES: Padres CF Cameron Maybin left the game during the top of the seventh inning with a stomach ailment. . Cain (left groin strain) was activated from 15-day DL and INF/OF Jimmy Paredes was optioned to Triple-A Omaha. . Royals RHP Jeremy Guthrie (2-2, 4.50 ERA) faces Padres LHP Robbie Erlin (1-4, 5.83) on Wednesday night.