Much has changed for the Arizona Diamondbacks and San Diego Padres since they last met in June.
Odrisamer Despaigne won his second major league start for San Diego in that contest although both these teams' infields will look vastly different now.
The visiting Padres start a three-game set with Despaigne on the mound Friday night as they try to hand the Diamondbacks a season-high seventh straight loss.
Arizona (53-75) has taken six of nine from San Diego, losing 2-1 on the road June 29. Despaigne (3-4, 3.28 ERA) yielded the one run in 6 2-3 innings.
The teams that take the field Friday will look drastically from that day.
Three of the Diamondbacks infielders that started that game won't be available since first baseman Paul Goldschmidt is out with a broken hand, third baseman Martin Prado has been traded and shortstop Nick Ahmed was sent to the minors Aug. 7. Right fielder Gerardo Parra also started in that game and has since been dealt.
San Diego (59-67) started third baseman Chase Headley and shortstop Irving Falu, both of whom are no longer with the team.
One constant for the Padres is Despaigne, who went 2-1 with a 1.31 ERA in his first five outings and is 1-3 with a 5.88 in five since. The right-hander gave up five runs over four innings Sunday in a 7-6 defeat at St. Louis.
"He just couldn't finish off any hitters," manager Bud Black said. "He couldn't get any of his pitches where he needed to get them."
Arizona has totaled 11 runs while hitting .199 in its last six games, as it tries to avoid its first seven-game losing streak since July 22-29, 2010. David Peralta is 5 for 23 in this skid, Aaron Hill is 2 for 19 and Miguel Montero is 3 for 17.
The Diamondbacks capped a 2-8 trip by being swept in four games in Washington. Thursday's 1-0 loss marked their sixth defeat by one run in this stretch.
"That's a credit to our pitching," slugger Mark Trumbo told MLB's official website. "We didn't give them any kind of support. Especially in this series, we didn't get the big hits when we needed whatsoever."
The Padres are making the final stop of a difficult 10-game trip after going 2-5 against two contenders, St. Louis and the Los Angeles Dodgers. They fell 2-1 to Clayton Kershaw and Los Angeles on Thursday.
The three singles San Diego mustered Thursday aren't indicative of an offense that is averaging an NL-best 4.5 runs since the All-Star break.
Seth Smith is hitting .333 since the break and Jedd Gyorko is batting .301 with four homers and 20 RBIs in his last 22 games.
Smith, Will Venable and rookie Jake Goebbert could all be in Friday's lineup after those lefty-swinging hitters did not start against Kershaw.
Smith is 5 for 14 against Diamondbacks right-handed starter Josh Collmenter (8-7, 4.31), who is 0-2 with a 8.50 ERA in his last four outings. Collmenter won his lone 2014 start against the Padres by allowing one run over 5 1-3 innings in a 3-1 victory June 28.