Kickoff: Sunday, 4:25 p.m. ET
Line: Arizona -1, Total: 41

NFC powerhouses clash Sunday when the 7-2 Lions head to the desert to take on the 8-1 Cardinals.

Here is the BetDSI Sportsbook betting preview for this matchup:

Detroit got WR Calvin Johnson (29 rec, 461 yards, 3 TD) back from an ankle injury last week and the superstar caught seven passes for 113 yards and a touchdown in a 20-16 victory over Atlanta, giving the team its fourth straight SU win. Arizona won its fifth straight game (SU and ATS) by a 31-14 score against the Rams, but starting QB Carson Palmer tore his ACL and will miss the remainder of the season. The Cardinals have dominated this series recently, going 10-5 SU (9-6 ATS) versus the Lions since 1992, which includes a 7-1 mark (SU and ATS) at home. Eight of the past 10 games played between these teams have gone Over the total. Since 1992, the Detroit is 38-21 ATS versus good rushing defenses that allow 90 or less rushing yards per game, while Arizona is 10-1 ATS versus defenses that allow a completion percentage of 61% or worse over the past two years. RB Reggie Bush (ankle) and TEs Joseph Fauria (ankle) and Eric Ebron (hamstring) are listed as questionable for the Lions, while two offensive linemen are considered doubtful due to knee injuries, G Larry Warford and OT LaAdrian Waddle. In addition to Palmer's injury, the Cardinals have two players considered questionable in RB Stepfan Taylor (calf) and LB Desmond Bishop (hamstring).

Which team will extend its win streak on Sunday? For the answer, connect to NFL Best Bets for all the StatFox Experts picks throughout the 2014 regular season and playoffs. The experts have remained hot over the past eight weeks, combining for a 58% ATS mark (72-52). StatFox Scott is 69% ATS (22-10) in Best Bets during this timeframe, and 63% ATS (25-15) on the season. StatFox Dave is 60% ATS (21-14) in Best Bets during these eight weeks to improve to 56% ATS (25-20) on the season, while StatFox Brian has gone 54% ATS (15-13) in NFL Best Bets since Week 3, and continues to roll in NFL Totals with a stellar 70% record (21-9) for the season. StatFox Gary is coming off a perfect 4-0 ATS mark in his Week 10 Best Bets.

The injury-riddled Lions have rarely been at full strength this season, but the team has found a way to gut out victories. QB Matthew Stafford (2,496 pass yards, 13 TD, 8 INT) threw for 280 yards with two touchdowns and one interception in the Lions’ victory over the Dolphins one week ago. Last season, Stafford threw for 278 yards with two touchdowns and no picks in a 25-21 loss in Arizona. His main target, WR Calvin Johnson (461 rec yards, 3 TD in 6 games) could have a tough game coming for him. Johnson will see plenty of time matched up against CB Patrick Peterson (2 INT), who is one of the best cover corners in football. If Johnson is not able to get open, then WR Golden Tate (66 rec, 909 yards, 3 TD) will likely be in for a huge game. Detroit is going to need to get its ground game going, which is why they could really miss RB Reggie Bush (191 rush yards, 1 TD) if he's unable to play. RB Joique Bell (357 rush yards, 3 TD) has rushed for just 131 yards on 42 carries (3.1 YPC) over the past three weeks. He is a good between-the-tackles runner, but the Lions are missing the explosiveness of Bush on the outside. This Detroit defense continues to dominate opponents, allowing just 212.1 passing yards per game (3rd in NFL) and 71.3 rushing yards per game (2nd in NFL).

With Carson Palmer out for the season, QB Drew Stanton (614 pass yards, 3 TD, 0 INT) is now starting under center for the Cardinals. Stanton played well in Palmer’s absence earlier in the season, most noticeably throwing for 244 yards with two touchdowns and no picks in a win over the 49ers. With Stanton at quarterback, the Cardinals will heavily feature RB Andre Ellington (582 rush yards, 3 TD). Ellington rushed for just 23 yards on 18 carries in the Cardinals’ win over St. Louis in the last game, but he did find the end zone once and also added five receptions for 19 yards through the air. It’s going to be a struggle for him to run against this Lions defensive front, but he’ll need to get it going if Arizona is going to win this game at home. WR Larry Fitzgerald (44 rec, 625 yards, 2 TD) had been heating up before Carson Palmer went down, but he’ll look to stay the course with Stanton under center. Fitzgerald had nine catches for 112 yards in the win over the Rams, and it was his second game with 100+ yards in the past three weeks. They Cardinals will keep targeting him in the offense, as he has been their most consistent receiver in recent weeks. Arizona’s defense is allowing only 78.6 rushing yards per game (3rd in NFL) but also a miserable 274.2 passing yards per game (30th in NFL). That is not a good combination as it faces a pass-heavy Lions team.