Kickoff: Sunday, 8:25 p.m. ET
Line: New England -3.5, Total: 51

The Patriots look to get back in the win column with a road victory against the Chargers on Sunday night.

New England was unable to defeat the Packers in Green Bay last week, losing 26-21 as a 3-point underdog. They team will now travel across the country and take on a Chargers club that has won three straight games (1-2 ATS), including a 34-33 win as a 6.5-point underdog in Baltimore on Sunday. New England has dominated this head-to-head series, going 9-3 SU (8-4 ATS) versus San Diego since 1992. The Patriots even won their most recent road meeting in this series back in 2010, prevailing 23-20 as 3-point underdogs. The Chargers have seemingly found their groove offensively, scoring 71 points over their past two games after tallying 13 total points in their two previous games. New England is 6-0 ATS after an SU loss over the past two seasons and 18-7 ATS in road games after a defeat by six or less points since 1992. The Chargers are, however, 18-7 ATS in home games after having won three out of their previous four games since 1992. While the Patriots' biggest injury is seldom-used WR Aaron Dobson (IR, hamstring), the Chargers could be missing three defensive players in DE Corey Liuget (knee), LB Andrew Gachkar (knee) and DT Ryan Carrethers (elbow).

Can the Chargers hand the Patriots another loss? For the answer, connect to NFL Best Bets for all the StatFox Experts picks throughout the 2014 regular season and playoffs. The experts have remained profitable since Week 3, combining for a 53.2% ATS mark (91-80). StatFox Dave is 56% ATS (27-21) in Best Bets during these 11 weeks to improve to 54.4% ATS (31-26) on the season. StatFox Gary is 69% ATS (9-4) in his past four weeks of NFL Best Bets, while StatFox Scott is 55% ATS (26-21) in Best Bets since Week 3. StatFox Brian continues to profit in NFL Totals with a 55% record (21-17) for the season.

The Patriots went into Green Bay last week and were unable to pick up what would have been a major statement victory. QB Tom Brady (3,243 pass yards, 28 TD, 6 INT) played well in the game, throwing for 245 yards and two touchdowns with no interceptions. He should be able to find some success against a Chargers defense that gave up 33 points and 376 passing yards to the Ravens a week ago. One guy that Brady will need to get going against this Chargers defense is TE Rob Gronkowski (65 rec, 910 yards, 9 TD). Gronkowski had seven receptions for 98 yards against the Packers and he’ll need to be on top of his game in this one. WR Brandon LaFell (53 rec, 712 yards, 7 TD) was excellent in the loss to the Packers, catching five passes for 38 yards and two touchdowns. LaFell’s emergence has taken a lot of pressure off Brady and he’ll certainly see plenty of targets against a defense that has not looked good against Shaun Hill and Joe Flacco over the past two weeks. This Patriots secondary didn’t pick Aaron Rodgers off last week, but they made things tough on him at times. They’ll need to make Chargers QB Philip Rivers more uncomfortable in the pocket or they could have trouble in this game.

Rivers (3,218 yards, 25 TD, 10 INT) threw for 383 yards and three touchdowns with just one interception while leading his team to a comeback victory in Baltimore last week. San Diego outscored the Ravens 21-10 in the fourth quarter to win the game, thanks largely to Philip Rivers’ performance. He’ll need to make plenty of adjustments at the line to keep the Patriots off guard. His ability to spread the ball around should somewhat neutralize the lockdown effect of Patriots CB Darrelle Revis (2 INT). The player most likely to see a lot of Revis is top WR Keenan Allen (72 rec, 762 yards, 4 TD), who has been on a tear recently. Allen has now gone over 100 yards two weeks in a row, including an 11-reception, 121-yard and 2-TD performance against the Ravens last week. Allen will need to be on his game in this one, as it won’t be easy to shake Revis when he’s lined up across from him. RB Ryan Mathews (284 rush yards, 3 TD) could be in for a big night, as the Patriots have struggled to stop inside runners this season. San Diego will have no chance of winning in this one if its defense can’t step it up. The Chargers have done poorly against some mediocre offenses in recent weeks, and now need to stop a potent Patriots team.