Kickoff: Sunday, 4:25 p.m. ET
Line: Dallas -3, Total: 56

Two of the league’s best teams clash on Sunday when the Colts put their four-game win streak on the line when they visit the Cowboys.

While Indianapolis secured its fourth straight SU victory (2-2 ATS) last week with a 17-10 win over Houston, Dallas picked up a statement victory with a 38-27 win as 3-point road underdogs against the Eagles. Cowboys RB DeMarco Murray (hand) is questionable for this game after undergoing hand surgery earlier in the week, but he says that he will play and contribute to the league’s third-best rushing attack. But a bigger concern for Dallas is finding a way to hold Andrew Luck in check, as the club is allowing 249.6 passing yards per game (23rd in NFL) and Luck is throwing for 301.9 YPG himself. However, Colts top WR T.Y. Hilton (groin) is questionable for Sunday, giving himself a 50/50 chance of playing. Over the past three seasons, the Colts are 12-2 ATS after an ATS defeat, but they are also 15-6 ATS when playing with six or less days of rest over the past two seasons. Dallas is, however, 32-16 ATS in home games after having won three out of its past four games since 1992. In addition to Hilton, Indianapolis could be missing three offensive linemen in OT Gosder Cherilus (groin), G Joe Reitz (ankle) and G Hugh Thornton (knee), who are all listed as questionable. Joining Murray on the questionable list for the Cowboys are LB Dekoda Watson (hamstring), DT Josh Brent (calf), OT Doug Free (ankle) and G Zack Martin (ankle).

Which team will pick up the crucial victory on Sunday? For the answer, connect to NFL Best Bets for all the StatFox Experts picks throughout the 2014 regular season and playoffs. StatFox Dave is 55% ATS (31-25-1) in Best Bets during the past 14 weeks, while StatFox Scott is also 55% ATS (29-24-1) in Best Bets since Week 3. StatFox Gary is 65% ATS (15-8-1) in his past seven weeks of NFL Best Bets, while StatFox Brian is on a 6-3 ATS run in the past three weeks.

The Colts beat the Texans 17-10 last week, but the win was far from pretty. QB Andrew Luck (4,492 yards, 38 TD, 14 INT) threw for just 187 yards in the game with two touchdowns and a pick. He has thrown four interceptions over the past three weeks and will need to take much better care of the football going forward. WR T.Y. Hilton (82 rec, 1,345 yards, 7 TD) had four catches for 50 yards before exiting the game with an injured groin. It would be a big loss for Indianapolis if he is unable to play against Dallas, but if Hilton does sit, WRs Reggie Wayne (59 rec, 665 yards, 2 TD) and Donte Moncrief (27 rec, 423 yards, 3 TD) will both need to step up and make plays for their quarterback. Moncrief has had two games with 100+ yards this season, showing that he is capable of playing at a high level with an increase in usage. Defensively, Indianapolis is going to really need to play a good game. DeMarco Murray is capable of really shredding any team he’s up against, and if he plays, the Colts defensive front will have a long game ahead of them. They did, however, hold Texans star back Arian Foster to 3.8 YPC a week ago, and have held the past four opponents to 103 rushing YPG on 3.6 YPC.

The Cowboys won a big game against the Eagles last week and will now look to give themselves some breathing room in the NFC East with a victory over the Colts. Defensively, this game is going to be really tough for Dallas, which has struggled to defend the pass this season, and now must find a way to stop one of the best quarterbacks in football. They Cowboys did intercept two Mark Sanchez passes last week though. Offensively, they will really need RB DeMarco Murray (1,687 rush yards, 11 TD) to play in this game. Murray has been one of the most consistently dominant running backs in the league this year and has given this team the balance it has lacked in recent years. QB Tony Romo (3,188 pass yards, 28 TD, 8 INT) threw for 265 yards with three touchdowns and no picks against the Eagles last week. He’s now tossed six touchdowns with zero interceptions over the past two games, and is really in a groove. WR Dez Bryant (79 rec, 1,148 yards, 13 TD) had six catches for 114 yards and three touchdowns against the Eagles. He is nearly impossible to keep in check, and Tony Romo will certainly be looking his way often in this game.