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OPENING LINE - Colts by 10

RECORD VS. SPREAD - San Francisco 4-1-1; Indianapolis 5-1

SERIES RECORD - Colts lead 23-18

LAST MEETING - Colts beat 49ers 28-3, Oct. 9, 2005

LAST WEEK - 49ers lost to Texans 24-21; Colts beat Rams 42-6

49ERS OFFENSE - OVERALL (29), RUSH (22), PASS (24)

49ERS DEFENSE - OVERALL (14), RUSH (6), PASS (21)

COLTS OFFENSE - OVERALL (4), RUSH (27), PASS (1)

COLTS DEFENSE - OVERALL (9), RUSH (19), PASS (6)

STREAKS, STATS AND NOTES - 49ers have not played in Indianapolis since November 2001. ... Two former No. 1 overall picks will be on field Sunday: Peyton Manning and San Francisco QB Alex Smith, who will be making first start of season. Smith also made NFL starting debut vs. Indy in 2005. ... San Francisco is 3-0 vs. NFC West, 0-3 vs. rest of NFL. ... RB Frank Gore is tied with Garrison Hearst for second in franchise history with 16 100-yard games. ... 49ers have only seven turnovers in six games after having 35 last season. ... Colts have won 15 straight regular-season games. Another win would make them eighth team in league history with 16-game streak. ... Coach Jim Caldwell could become first rookie coach since the 1970 merger to open his career 7-0. Denver's Josh McDaniels is also 6-0 and has an early game Sunday in Baltimore. ... Manning needs five TD passes to reach 20 for the 12th time in 12 NFL seasons. ...DE Dwight Freeney has had a sack in seven straight games. DE Robert Mathis holds franchise record (eight). ... A win would give Indy four-game sweep of the NFC West for the first time since moving from Baltimore in 1984.

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