DETROIT (AP) -Lions quarterback Matthew Stafford was active and receiver Calvin Johnson was out against the St. Louis Rams.

Dennis Northcutt replaced Johnson in Detroit's lineup Sunday.

Stafford missed two games with an injured right knee. He was able to rest last week because Detroit had a bye.

The No. 1 pick in the NFL draft threw three touchdowns and six interceptions in his first four games. He helped the Lions win in Week 3 win against Washington to end their 19-game losing streak.

Johnson did not play in the Lions' previous game, a 26-0 loss at Green Bay, after injuring his right knee Oct. 11 against the Steelers. He has 22 receptions for 325 yards receiving and a TD this year. Last season, Johnson had 12 TD receptions.