SAN FRANCISCO (AP) -San Francisco 49ers wide receiver Isaac Bruce is inactive against the Chicago Bears with an ankle injury.

Bruce is being replaced in the starting lineup Thursday night by rookie Michael Crabtree. Other players inactive for San Francisco are defensive backs Nate Clements and Keith Smith; running back Glen Coffee; offensive linemen Cody Wallace and Joe Staley; and defensive lineman Demetric Evans. Nate Davis is the third quarterback.

Chicago will be without starting safety Al Afalava, who has a shoulder injury. The other players inactive for the Bears are receiver Juaquin Iglesias, running back Garrett Wolfe, safety Kevin Payne, linebacker Pisa Tinoisamoa, offensive lineman Lance Louis, and defensive lineman Matt Toeaina and Jarron Gilbert.