SANTA CLARA, Calif. (AP) - San Francisco 49ers running back Kendall Hunter is the second player in two days to be lost for the year after he and wide receiver Kyle Williams were hurt on the same play in Sunday's win at New Orleans.

The 49ers said Tuesday both players had been placed on season-ending injured reserve. Williams announced Monday on Twitter that he tore the anterior cruciate ligament in his left knee, while Hunter is listed out with an ankle injury - though some of his teammates said he was undergoing treatment on his left Achilles tendon.

NFC West-leading San Francisco (8-2-1) activated running back Jewel Hampton from the non-football injury list and added him to the 53-man roster.

The 49ers released safety Eddie Whitley from the practice squad and signed wideout and returner Chad Hall to the practice squad.

---

Online: http://pro32.ap.org/poll and http://twitter.com/AP-NFL